Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Towards therapeutic base editing


Base editors function in mouse fetuses and in the livers of adult mice to treat a genetic disorder.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Base editing can be applied therapeutically for metabolic disorders.


  1. Komor, A. C. et al. Nature 533, 420–424 (2016).

    Article  CAS  Google Scholar 

  2. Nishida, K. et al. Science 353, aaf8729 (2016).

    Article  Google Scholar 

  3. Gaudelli, N. M. et al. Nature 551, 464–471 (2017).

    Article  CAS  Google Scholar 

  4. Li, X. et al. Nat. Biotechnol. 36, 324–327 (2018).

    Article  CAS  Google Scholar 

  5. Kim, K. et al. Nat. Biotechnol. 35, 435–437 (2017).

    Article  CAS  Google Scholar 

  6. Ryu, S. M. et al. Nat. Biotechnol. 36, 536–539 (2018).

    Article  CAS  Google Scholar 

  7. Zafra, M. P. et al. Nat. Biotechnol. 36, 888–893 (2018).

    Article  CAS  Google Scholar 

  8. Rossidis, A. C. et al. Nat. Med. (2018).

  9. Villiger, L. et al. Nat. Med. (2018).

  10. Veltman, J. A. et al. Nat. Rev. Genet. 13, 565–575 (2012).

    Article  CAS  Google Scholar 

  11. Kitzman, J. O. et al. Sci. Transl. Med. 4, 137ra76 (2012).

    Article  Google Scholar 

  12. Kim, Y. B. et al. Nat. Biotechnol. 35, 371–376 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Jin-Soo Kim.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Seo, H., Kim, JS. Towards therapeutic base editing. Nat Med 24, 1493–1495 (2018).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research