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GENE THERAPY

Towards therapeutic base editing

Nature Medicine volume 24, pages 1493–1495 (2018)Cite this article

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Base editors function in mouse fetuses and in the livers of adult mice to treat a genetic disorder.

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Fig. 1: Base editing can be applied therapeutically for metabolic disorders.

References

  1. Komor, A. C. et al. Nature 533, 420–424 (2016).

    Article  CAS  Google Scholar 

  2. Nishida, K. et al. Science 353, aaf8729 (2016).

    Article  Google Scholar 

  3. Gaudelli, N. M. et al. Nature 551, 464–471 (2017).

    Article  CAS  Google Scholar 

  4. Li, X. et al. Nat. Biotechnol. 36, 324–327 (2018).

    Article  CAS  Google Scholar 

  5. Kim, K. et al. Nat. Biotechnol. 35, 435–437 (2017).

    Article  CAS  Google Scholar 

  6. Ryu, S. M. et al. Nat. Biotechnol. 36, 536–539 (2018).

    Article  CAS  Google Scholar 

  7. Zafra, M. P. et al. Nat. Biotechnol. 36, 888–893 (2018).

    Article  CAS  Google Scholar 

  8. Rossidis, A. C. et al. Nat. Med. https://doi.org/10.1038/s41591-018-0184-6 (2018).

  9. Villiger, L. et al. Nat. Med. https://doi.org/10.1038/s41591-018-209-1 (2018).

  10. Veltman, J. A. et al. Nat. Rev. Genet. 13, 565–575 (2012).

    Article  CAS  Google Scholar 

  11. Kitzman, J. O. et al. Sci. Transl. Med. 4, 137ra76 (2012).

    Article  Google Scholar 

  12. Kim, Y. B. et al. Nat. Biotechnol. 35, 371–376 (2017).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Center for Genome Engineering, Institute for Basic Science, Daejon, South Korea

    Huiyun Seo & Jin-Soo Kim

  2. Department of Chemistry, Seoul National University, Seoul, South Korea

    Jin-Soo Kim

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  1. Huiyun Seo
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  2. Jin-Soo Kim
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Correspondence to Jin-Soo Kim.

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The authors declare no competing interests.

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Seo, H., Kim, JS. Towards therapeutic base editing. Nat Med 24, 1493–1495 (2018). https://doi.org/10.1038/s41591-018-0215-3

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