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GENE THERAPY

Towards therapeutic base editing

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Base editors function in mouse fetuses and in the livers of adult mice to treat a genetic disorder.

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Fig. 1: Base editing can be applied therapeutically for metabolic disorders.

References

  1. Komor, A. C. et al. Nature 533, 420–424 (2016).

    CAS  Article  Google Scholar 

  2. Nishida, K. et al. Science 353, aaf8729 (2016).

    Article  Google Scholar 

  3. Gaudelli, N. M. et al. Nature 551, 464–471 (2017).

    CAS  Article  Google Scholar 

  4. Li, X. et al. Nat. Biotechnol. 36, 324–327 (2018).

    CAS  Article  Google Scholar 

  5. Kim, K. et al. Nat. Biotechnol. 35, 435–437 (2017).

    CAS  Article  Google Scholar 

  6. Ryu, S. M. et al. Nat. Biotechnol. 36, 536–539 (2018).

    CAS  Article  Google Scholar 

  7. Zafra, M. P. et al. Nat. Biotechnol. 36, 888–893 (2018).

    CAS  Article  Google Scholar 

  8. Rossidis, A. C. et al. Nat. Med. https://doi.org/10.1038/s41591-018-0184-6 (2018).

  9. Villiger, L. et al. Nat. Med. https://doi.org/10.1038/s41591-018-209-1 (2018).

  10. Veltman, J. A. et al. Nat. Rev. Genet. 13, 565–575 (2012).

    CAS  Article  Google Scholar 

  11. Kitzman, J. O. et al. Sci. Transl. Med. 4, 137ra76 (2012).

    Article  Google Scholar 

  12. Kim, Y. B. et al. Nat. Biotechnol. 35, 371–376 (2017).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Jin-Soo Kim.

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Seo, H., Kim, JS. Towards therapeutic base editing. Nat Med 24, 1493–1495 (2018). https://doi.org/10.1038/s41591-018-0215-3

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  • DOI: https://doi.org/10.1038/s41591-018-0215-3

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