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Tumors evading CARs—the chase is on

Acquired resistance to CD19-targeted CAR T cell therapy can occur through mutations in the CD19 gene or after insertion of a chimeric antigen receptor (CAR) into leukemia cells, resulting in the adjacent receptor being masked by the CAR.

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Fig. 1: CD19 antigen escape from CAR T cell therapy.


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Correspondence to Renier J. Brentjens.

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R.J.B. is a cofounder of and receives royalties from Juno Therapeutics.

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Rafiq, S., Brentjens, R.J. Tumors evading CARs—the chase is on. Nat Med 24, 1492–1493 (2018).

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