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Preconception cold–induced epigenetic inheritance

Preconception cold–induced alterations of sperm DNA methylation result in offspring with altered brown adipose tissue and improved adaptation to overnutrition and hypothermia.

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Fig. 1: Preconception exposure to cold alters offspring traits.


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I thank H. Johnson for assistance in preparation of this manuscript. This work was supported by grants from the National Institutes of Health (NIH; ES012974) and the John Templeton Foundation (50183) to M.K.S.

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Correspondence to Michael K. Skinner.

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Skinner, M.K. Preconception cold–induced epigenetic inheritance. Nat Med 24, 1308–1309 (2018).

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