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KIDNEY DISEASES

Modulating NAD+ metabolism to prevent acute kidney injury

Nature Medicine volume 24, pages 1306–1307 (2018)Cite this article

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Impaired de novo NAD+ biosynthesis predisposes to acute kidney injury, and augmenting NAD+ metabolism with oral nicotinamide supplementation may prevent acute kidney injury.

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Fig. 1: Mehr et al.4 provide three key findings for patients at risk of developing AKI.

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Acknowledgements

D.J.H. was supported by the British Heart Foundation (FS/10/039/28270), the National Institute for Health Research University College London Hospitals Biomedical Research Centre, Duke-National University Singapore Medical School, Singapore Ministry of Health’s National Medical Research Council under its Clinician Scientist-Senior Investigator scheme (NMRC/CSA-SI/0011/2017) and Collaborative Centre Grant scheme (NMRC/CGAug16C006) and the Singapore Ministry of Education Academic Research Fund Tier 2 (MOE2016-T2-2-021). This article is based upon work from COST Action EU-CARDIOPROTECTION CA16225 supported by COST (European Cooperation in Science and Technology).

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Authors and Affiliations

  1. Norfolk and Norwich University Hospital, Norfolk, UK

    Heerajnarain Bulluck

  2. The Hatter Cardiovascular Institute, University College London, London, UK

    Derek J. Hausenloy

  3. National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK

    Derek J. Hausenloy

  4. National Heart Centre, Singapore, Singapore

    Derek J. Hausenloy

  5. Barts Heart Centre, St Bartholomew’s Hospital, London, UK

    Derek J. Hausenloy

  6. Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore

    Derek J. Hausenloy

  7. Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore

    Derek J. Hausenloy

Authors
  1. Heerajnarain Bulluck
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  2. Derek J. Hausenloy
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Correspondence to Derek J. Hausenloy.

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Bulluck, H., Hausenloy, D.J. Modulating NAD+ metabolism to prevent acute kidney injury. Nat Med 24, 1306–1307 (2018). https://doi.org/10.1038/s41591-018-0181-9

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