Microbiome

Microbiome metabolomics reveals new drivers of human liver steatosis

An integrative multiomics approach in nondiabetic obese women identifies phenylacetate as a microbial metabolite contributing to the accumulation of lipids in the liver and hence to nonalcoholic steatohepatitis.

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Fig. 1: The gut microbiota contributes to hepatic steatosis.

Marina Spence/Springer Nature

References

  1. 1.

    Postler, T. S. & Ghosh, S. Cell Metab. 26, 110–130 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  2. 2.

    Claus, S. P. et al. Mol. Syst. Biol 4, 219 (2008).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. 3.

    Delzenne, N. M. & Bindels, L. B. Nat. Rev. Gastroenterol. Hepatol. 15, 69–70 (2017).

    Article  PubMed  Google Scholar 

  4. 4.

    Hoyles, L. Nat. Med. https://doi.org/10.1038/s41591-018-0061-3 (2018).

  5. 5.

    Russell, W. R. et al. Mol. Nutr. Food Res. 57, 523–535 (2013).

    Article  PubMed  CAS  Google Scholar 

  6. 6.

    Koppel, N., Maini Rekdal, V. & Balskus, E. P. Science 356, eaag2770 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

Download references

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Correspondence to Nathalie M. Delzenne.

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Delzenne, N.M., Bindels, L.B. Microbiome metabolomics reveals new drivers of human liver steatosis. Nat Med 24, 906–907 (2018). https://doi.org/10.1038/s41591-018-0126-3

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