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Gene therapy

A path to efficient gene editing

Nature Medicinevolume 24pages899900 (2018) | Download Citation

Signaling by the tumor-suppressor protein p53 antagonizes CRISPR–Cas9 gene editing of human pluripotent stem cells and immortalized human retinal pigment epithelial cells.

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Author information

Affiliations

  1. Altius Institute for Biomedical Sciences, Seattle, WA, USA

    • Fyodor D. Urnov

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The author declares no competing interests.

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Correspondence to Fyodor D. Urnov.

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DOI

https://doi.org/10.1038/s41591-018-0110-y

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