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Gene therapy

A path to efficient gene editing

Signaling by the tumor-suppressor protein p53 antagonizes CRISPR–Cas9 gene editing of human pluripotent stem cells and immortalized human retinal pigment epithelial cells.

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Fig. 1: Induction of p53 contributes to inefficient gene editing in hPSCs.

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Correspondence to Fyodor D. Urnov.

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Urnov, F.D. A path to efficient gene editing. Nat Med 24, 899–900 (2018).

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