Figure 1: Nature Medicine

Fig. 1: Overview of the 52,698 single cells from lung tumors and distal non-malignant lung samples.

From: Phenotype molding of stromal cells in the lung tumor microenvironment

Fig. 1

a, Summary of the sample origins. COPD classification according to Global Initiative for Chronic Obstructive Lung Disease staging. b, tSNE of the 52,698 cells profiled here, with each cell color-coded for (left to right): its sample type of origin (tumor or non-malignant lung), the corresponding patient, the associated cell type and the number of transcripts (UMIs) detected in that cell (log scale as defined in the inset). K, thousand. c, Expression of marker genes for the cell types defined above each panel. Three additional marker genes for each cell type are shown in Supplementary Fig. 1. d, For each of the 52 stromal cell subclusters and the 12 cancer cell subclusters (left to right): the fraction of cells originating from the 4 non-malignant and 15 tumor samples, the fraction of cells originating from each of the 5 patients, the number of cells and box plots of the number of transcripts (with plot center, box and whiskers corresponding to median, IQR and 1.5 × IQR, respectively; n per boxplot is shown in the ‘number of cells’ panel, and specified in Supplementary Table 3).