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IMMUNOTHERAPY

Modeling cytokine release syndrome

Nature Medicine volume 24, pages 705–706 (2018)Cite this article

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Complete leukemic responses to chimeric antigen receptor–modified T cells are invariably accompanied by severe toxicity. Recently developed animal models allow mechanistic dissection and prevention of toxicity without loss of therapeutic benefit.

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Fig. 1: Modeling CRS after CAR T cell transfer in mice reveals macrophages to be key players in the development of CRS and neurotoxicity.

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Authors and Affiliations

  1. Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA

    Cliona Rooney & Tim Sauer

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  1. Cliona Rooney
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  2. Tim Sauer
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Correspondence to Cliona Rooney.

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The authors declare no competing interests.

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Rooney, C., Sauer, T. Modeling cytokine release syndrome. Nat Med 24, 705–706 (2018). https://doi.org/10.1038/s41591-018-0068-9

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