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Modeling cytokine release syndrome

Complete leukemic responses to chimeric antigen receptor–modified T cells are invariably accompanied by severe toxicity. Recently developed animal models allow mechanistic dissection and prevention of toxicity without loss of therapeutic benefit.

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Fig. 1: Modeling CRS after CAR T cell transfer in mice reveals macrophages to be key players in the development of CRS and neurotoxicity.


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Correspondence to Cliona Rooney.

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The authors declare no competing interests.

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Rooney, C., Sauer, T. Modeling cytokine release syndrome. Nat Med 24, 705–706 (2018).

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