Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

IMMUNOTHERAPY

Modeling cytokine release syndrome

Complete leukemic responses to chimeric antigen receptor–modified T cells are invariably accompanied by severe toxicity. Recently developed animal models allow mechanistic dissection and prevention of toxicity without loss of therapeutic benefit.

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Modeling CRS after CAR T cell transfer in mice reveals macrophages to be key players in the development of CRS and neurotoxicity.

References

  1. 1.

    Schmiegelow, K. et al. Lancet Oncol. 17, e231–e239 (2016).

    Article  PubMed  Google Scholar 

  2. 2.

    Porter, D., Frey, N., Wood, P. A., Weng, Y. & Grupp, S. A. J. Hematol. Oncol. 11, 35 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  3. 3.

    Turtle, C. J. et al. Sci. Transl. Med. 8, 355ra116 (2016).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. 4.

    Gust, J. et al. Cancer Discov. 7, 1404–1419 (2017).

    Article  PubMed  CAS  Google Scholar 

  5. 5.

    Morgan, R. A. Mol. Ther. 20, 882–884 (2012).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. 6.

    Norelli, M., et al. Nat. Med. https://doi.org/10.1038/s41591-018-0036-4 (2018).

  7. 7.

    Giavridis, T., et al. Nat. Med. https://doi.org/10.1038/s41591-018-0041-7 (2018).

  8. 8.

    Bedoya, F., Frigault, M. J. & Maus, M. V. Mol. Ther. 25, 314–320 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. 9.

    Shultz, L. D. et al. J. Immunol. 154, 180–191 (1995).

    PubMed  CAS  Google Scholar 

  10. 10.

    Hay, K. A. et al. Blood 130, 2295–2306 (2017).

    Article  PubMed  CAS  Google Scholar 

  11. 11.

    Shum, T. et al. Cancer Discov. 7, 1238–1247 (2017).

    Article  PubMed  CAS  Google Scholar 

  12. 12.

    Cruz, C. R. et al. Cytotherapy 12, 743–749 (2010).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Cliona Rooney.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Rooney, C., Sauer, T. Modeling cytokine release syndrome. Nat Med 24, 705–706 (2018). https://doi.org/10.1038/s41591-018-0068-9

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing