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Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys

Nature Medicine volume 24, pages 721–723 (2018)Cite this article

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Abstract

Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV)-endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potently cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV.

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Fig. 1: Characterization and pharmacokinetics of B10.
Fig. 2: Therapeutic and prophylactic efficacy of B10 in rhesus monkeys.

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Acknowledgements

We thank V. Cao-Lormeau (Unit of Emerging Infectious Diseases, Institut Louis Malardé; provided Zika virus strain PF-13), E. Moseley, K. McMahan, M. Boyd, M. Kirilova, O. Nanayakkara, Z. Li, N. Mercado, A. Badamchi-Zadeh, M. Iampietro, C. Bricault, P. Gandhi, S. Khatiwada, S. Mojta, B. Alimonti, A. Chandrashekar, A. Brinkman, M. Ferguson, and W. Rinaldi for generous advice, assistance, and reagents. We acknowledge support from the US National Institutes of Health (AI124377, AI126603, AI128751, AI129797) (D.H.B.), the National Institute for Health Research Biomedical Research Centre funding scheme UK (G.R.S), MRC-Newton UK (J.M.), and the Ragon Institute of MGH, MIT, and Harvard (D.H.B.). G.R.S. is a Wellcome Trust Senior Investigator.

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Author notes

  1. These authors contributed equally: Peter Abbink, Rafael A. Larocca, Wanwisa Dejnirattisai.

Authors and Affiliations

  1. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Peter Abbink, Rafael A. Larocca, Rebecca Peterson, Joseph P. Nkolola, Erica N. Borducchi & Dan H. Barouch

  2. Division of Immunology and Inflammation, Department of Medicine, Hammersmith Campus, Imperial College, London, UK

    Wanwisa Dejnirattisai, Piyada Supasa & Juthathip Mongkolsapaya

  3. Dengue Hemorrhagic Fever Research Unit, Office for Research and Development, Siriraj Hospital, Faculty of Medicine, Mahidol Univeristy, Bangkok, Thailand

    Juthathip Mongkolsapaya

  4. Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK

    Gavin R. Screaton

  5. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA

    Dan H. Barouch

Authors
  1. Peter Abbink
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  2. Rafael A. Larocca
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  7. Piyada Supasa
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  8. Juthathip Mongkolsapaya
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  9. Gavin R. Screaton
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  10. Dan H. Barouch
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Contributions

D.H.B. and G.R.S. designed the studies. W.D., P.S., and J.M. produced and characterized the B10 antibody. R.A.L. conducted the mouse studies. P.A. and R.P. conducted the virologic assays. J.P.N. and E.N.B. conducted the monkey study and immunologic assays. D.H.B. wrote the paper with all coauthors.

Corresponding authors

Correspondence to Gavin R. Screaton or Dan H. Barouch.

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Competing interests

The B10 antibody is the subject of patents held by Imperial College and Institute Pasteur on which G.R.S., W.D., and J.M. are inventors.

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Abbink, P., Larocca, R.A., Dejnirattisai, W. et al. Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys. Nat Med 24, 721–723 (2018). https://doi.org/10.1038/s41591-018-0056-0

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