The G396R coding variant in IGHG1, which encodes membrane-bound IgG1 heavy chain, might have arisen within the Southeast Asian population as a potential evolutionary event on an archaic haplotype background. This variant potentiates immune resilience against various life-threatening organisms, illustrating the interplay of human evolution and immune adaptation.
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References
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This is a summary of: Sun, W. et al. An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms. Nat. Immunol. https://doi.org/10.1038/s41590-024-01944-4 (2024).
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A B cell receptor variant confers evolutionary protection against pathogens. Nat Immunol 25, 1791–1792 (2024). https://doi.org/10.1038/s41590-024-01953-3
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DOI: https://doi.org/10.1038/s41590-024-01953-3
