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Cancer immunology

A pinch of salt boosts T cell function

Nature Immunology volume 25, pages 1772–1774 (2024)Cite this article

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Effector CD8+ T cells with cytotoxic ability are crucial for immunotherapy success. Two studies show that salt (NaCl) supplementation can enhance the effector function of CD8+ T cells and boost their antitumor responses.

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Fig. 1: CD8+ T cell alterations induced by NaCl supplementation.

References

  1. Bader, J. E., Voss, K. & Rathmell, J. C. Mol. Cell 78, 1019–1033 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Scirgolea, C. et al. Nat. Immunol. https://doi.org/10.1038/s41590-024-01923-9 (2024).

    Article  PubMed  Google Scholar 

  3. Soll, D. et al. Nat. Immunol. https://doi.org/10.1038/s41590-024-01918-6 (2024).

    Article  PubMed  Google Scholar 

  4. Franco, F., Jaccard, A., Romero, P., Yu, Y. R. & Ho, P. C. Nat Metab 2, 1001–1012 (2020).

    Article  CAS  PubMed  Google Scholar 

  5. Eil, R. et al. Nature 537, 539–543 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Lötscher, J. et al. Cell 185, 585–602.e29 (2022).

    Article  PubMed  Google Scholar 

  7. He, W. et al. Nat. Commun. 11, 1732 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Hernandez, A. L. et al. J. Clin. Invest. 125, 4212–4222 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Côrte-Real, B. F. et al. Cell Metab. 35, 299–315.e8 (2023).

    Article  PubMed  Google Scholar 

  10. Liu, P. S. et al. Nat. Immunol. 18, 985–994 (2017).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Oncology, University of Lausanne, Lausanne, Switzerland

    Karina L. Hajdu, Lorène Rousseau & Ping-Chih Ho

  2. Ludwig Institute for Cancer Research, University of Lausanne, Épalinges, Switzerland

    Karina L. Hajdu, Lorène Rousseau & Ping-Chih Ho

Authors
  1. Karina L. Hajdu
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  2. Lorène Rousseau
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  3. Ping-Chih Ho
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Corresponding author

Correspondence to Ping-Chih Ho.

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Competing interests

P.-C.H. serves as a member of scientific advisory boards for Celyad Oncology and Elixiron Immunotherapeutics and is a co-founder of Pilatus Biosciences. The other authors declare no competing interests.

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Hajdu, K.L., Rousseau, L. & Ho, PC. A pinch of salt boosts T cell function. Nat Immunol 25, 1772–1774 (2024). https://doi.org/10.1038/s41590-024-01946-2

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