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Gene regulation

A balancing act in the control of self-antigen expression

Nature Immunology volume 25, pages 1520–1521 (2024)Cite this article

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The AIRE protein drives the expression of tissue-restricted self-antigens, required to induce immune tolerance for self-proteins. New work shows the importance of an external interaction between AIRE and the transcriptional activator CBP/p300, and an internal competition for nuclear-condensate formation.

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Fig. 1: Structural domains of AIRE.

References

  1. Nagamine, K. et al. Nat. Genet. 17, 393–398 (1997).

    Article  CAS  PubMed  Google Scholar 

  2. Anderson, M. S. et al. Science 298, 1395–1401 (2002).

    Article  CAS  PubMed  Google Scholar 

  3. Miller, C. N., Waterfield, M. R., Gardner, J. M. & Anderson, M. S. Annu. Rev. Immunol. 42, 427–453 (2024).

    Article  PubMed  Google Scholar 

  4. Givony, T. et al. Nature 622, 164–172 (2023).

    Article  CAS  PubMed  Google Scholar 

  5. Michelson, D. A., Hase, K., Kaisho, T., Benoist, C. & Mathis, D. Cell 185, 2542–2558 e2518 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Anderson, M. S. et al. Immunity 23, 227–239 (2005).

    Article  CAS  PubMed  Google Scholar 

  7. Huoh, Y.-S. et al. Nat. Immunol. https://doi.org/10.1038/s41590-024-01922-w (2024).

    Article  PubMed  Google Scholar 

  8. Guerau-de-Arellano, M., Mathis, D. & Benoist, C. Proc. Natl Acad. Sci. USA 105, 14011–14016 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Abramson, J., Giraud, M., Benoist, C. & Mathis, D. Cell 140, 123–135 (2010).

    Article  CAS  PubMed  Google Scholar 

  10. Waterfield, M. et al. Nat. Immunol. 15, 258–265 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Giraud, M. et al. Proc. Natl Acad. Sci. USA 109, 535–540 (2012).

    Article  CAS  PubMed  Google Scholar 

  12. Bansal, K., Yoshida, H., Benoist, C. & Mathis, D. Nat. Immunol. 18, 263–273 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Rinderle, C., Christensen, H. M., Schweiger, S., Lehrach, H. & Yaspo, M. L. Hum. Mol. Genet. 8, 277–290 (1999).

    Article  CAS  PubMed  Google Scholar 

  14. Huoh, Y. S. et al. Nat. Commun. 11, 1625 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Koh, A. S., Kingston, R. E., Benoist, C. & Mathis, D. Proc. Natl Acad. Sci. USA 107, 13016–13021 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Org, T. et al. EMBO Rep. 9, 370–376 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Pitkanen, J. et al. Biochem. Biophys. Res. Commun. 333, 944–953 (2005).

    Article  CAS  PubMed  Google Scholar 

  18. Saare, M., Rebane, A., Rajashekar, B., Vilo, J. & Peterson, P. Exp. Cell Res. 318, 1767–1778 (2012).

    Article  CAS  PubMed  Google Scholar 

  19. Fang, Y., Bansal, K., Mostafavi, S., Benoist, C. & Mathis, D. Nature 628, 400–407 (2024).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA

    Michael R. Waterfield

  2. Diabetes Center, University of California, San Francisco, San Francisco, CA, USA

    Mark S. Anderson

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  1. Michael R. Waterfield
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  2. Mark S. Anderson
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Correspondence to Mark S. Anderson.

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The authors declare no competing interests.

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Waterfield, M.R., Anderson, M.S. A balancing act in the control of self-antigen expression. Nat Immunol 25, 1520–1521 (2024). https://doi.org/10.1038/s41590-024-01940-8

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