TNIP1, a previously identified risk factor for autoimmunity, regulates mitochondrial autophagosomal trafficking. Missense mutations in TNIP1 disrupt this regulatory function, yielding a B cell-intrinsic predisposition for TLR7-mediated autoimmunity characterized by IgG4 autoantibodies and the expansion of age-associated B cells.
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Cancro, M.P., Marshak-Rothstein, A. Directing risky traffic in B cells with TNIP1. Nat Immunol 25, 1522–1523 (2024). https://doi.org/10.1038/s41590-024-01913-x
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DOI: https://doi.org/10.1038/s41590-024-01913-x
