We constructed a humanized (THX) mouse by grafting non-γ-irradiated, genetically myeloablated immunodeficient mouse neonates with human cord blood CD34+ cells, followed by 17β-estradiol hormonal conditioning. THX mice develop a human lymphoid and myeloid immune system, mount mature antibacterial and antiviral neutralizing antibody responses, and are amenable to develop lupus autoimmunity.
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This is a summary of: Chupp, D. P. et al. A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses. Nat. Immunol. https://doi.org/10.1038/s41590-024-01880-3 (2024).
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A humanized mouse that mounts specific and mature antibody and autoantibody responses. Nat Immunol 25, 1326–1327 (2024). https://doi.org/10.1038/s41590-024-01908-8
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DOI: https://doi.org/10.1038/s41590-024-01908-8
