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Lymphoid TCF1+CD39+CD8+ T cells maintain stem-like features and contribute to viral control

Improved understanding of CD8+ T cell function during HIV infection is vital to designing an HIV cure. We have identified a subset of lymph node CD8+ T cells that demonstrate simultaneous stem-like and effector properties and are strongly associated with viral control during SIV and HIV infection.

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Fig. 1: TCF1+CD39+CD8+ T cells expand after SIV infection.

References

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This is a summary of: Strongin, Z. et al. Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence. Nat. Immunol. https://doi.org/10.1038/s41590-024-01875-0 (2024).

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Lymphoid TCF1+CD39+CD8+ T cells maintain stem-like features and contribute to viral control. Nat Immunol 25, 1142–1143 (2024). https://doi.org/10.1038/s41590-024-01889-8

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