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Genetics determines how environmental change alters immune phenotypes

Variation in inter-individual immune phenotypes can be influenced by both genetics and environmental factors. Using a range of different inbred strains of mice that were kept either indoors or in an outdoor enclosure — ‘rewilded’ — we found that both genetics and environment combine to dictate an individual’s immune profile and outcome to parasitic helminth infections.

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Fig. 1: Genotype and environment interactions drive immune variation in mouse PBMCs and MLN tissues.

References

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This is a summary of: Oyesola, O. et al. Genetic and environmental interactions contribute to immune variation in rewilded mice. Nat. Immunol. https://doi.org/10.1038/s41590-024-01862-5 (2024).

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Genetics determines how environmental change alters immune phenotypes. Nat Immunol 25, 1138–1139 (2024). https://doi.org/10.1038/s41590-024-01879-w

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