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Non-hierarchically related HSCs replenish platelets by distinct progenitor pathways

Genetic lineage tracing and progenitor and multilineage fate mapping after single hematopoietic stem cell (HSC) transplantations identify two distinct HSC-progenitor trajectories for the replenishment of platelets in mice. These pathways include a slower multilineage pathway and a faster platelet-restricted or biased pathway, initiated by distinct and non-hierarchically related HSCs.

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Fig. 1: Alternative progenitor pathways initiated by distinct HSCs.

References

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This is a summary of: Carrelha, J. et al. Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells. Nat. Immunol. https://doi.org/10.1038/s41590-024-01845-6 (2024).

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Non-hierarchically related HSCs replenish platelets by distinct progenitor pathways. Nat Immunol 25, 955–956 (2024). https://doi.org/10.1038/s41590-024-01878-x

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