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Cancer immunology

Colorectal cancer clocks in on TIME

Immune responses are subject to circadian regulation, but circadian effects on antitumor immune response are unknown. Disruption of intestinal circadian rhythms is now shown to promote immunosuppression by altering the tumor immune microenvironment (TIME) in colorectal cancer.

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Fig. 1: Circadian disruption of intestinal epithelium alters the immune landscape.

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Correspondence to Brian J. Altman.

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Knudsen-Clark, A.M., Altman, B.J. Colorectal cancer clocks in on TIME. Nat Immunol 25, 1133–1135 (2024). https://doi.org/10.1038/s41590-024-01874-1

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