Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Host–pathogen interactions

Mycobacterial d-serine impairs TB control

Adaptation to hypoxia and immune escape are two hallmarks of Mycobacterium tuberculosis infection. The d-serine isomer has now been identified as a factor produced by M. tuberculosis upon hypoxic conditions, dampening CD8+ T cell responses.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: d-serine secretion by Mycobacterium tuberculosis promotes immune escape.

References

  1. Cohen, S. B. et al. Cell Host Microbe 24, 439–446.e4 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Cohen, S. B., Gern, B. H. & Urdahl, K. B. Annu. Rev. Immunol. 40, 589–614 (2022).

    Article  CAS  PubMed  Google Scholar 

  3. Cheng, H. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-024-01701-1 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Galagan, J. E. et al. Nature 499, 178–183 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Mayer-Barber, K. D. & Barber, D. L. Cold Spring Harb. Perspect. Med. 5, a01842 (2015).

    Google Scholar 

  6. Woodworth, J. S. M. & Behar, S. M. Crit. Rev. Immunol. 26, 317–352 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Winchell, C. G. et al. J. Exp. Med. 220, e20230707 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Schurr, E. et al. Preprint at Research Square https://doi.org/10.21203/rs.3.rs-3889020/v1 (2024).

  9. Kramnik, I., Dietrich, W. F., Demant, P. & Bloom, B. R. Proc. Natl Acad. Sci. USA 97, 8560–8565 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Ji, D. X. et al. Elife 10, e67290 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Sasabe, J. et al. Nat. Microbiol. 1, 16125 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Olivier Neyrolles.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Caouaille, M., Hudrisier, D. & Neyrolles, O. Mycobacterial d-serine impairs TB control. Nat Immunol 25, 1129–1130 (2024). https://doi.org/10.1038/s41590-024-01873-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-024-01873-2

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing