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Immunometabolism

Glucose restriction in antiviral defence

Immune cells coordinate β-cell insulin secretion to regulate glucose levels and promote type I interferon production to control systemic viral infection.

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Fig. 1: Regulation of glucose levels in systemic viral infection.

References

  1. Wilfahrt, D. & Delgoffe, G. M. Nat. Immunol. 25, 206–217 (2024).

    Article  CAS  PubMed  Google Scholar 

  2. Willmann, K. & Moita, L. F. Cell Metab. https://doi.org/10.1016/j.cmet.2024.02.013 (2024).

    Article  PubMed  Google Scholar 

  3. Lercher, A., Baazim, H. & Bergthaler, A. Immunity 53, 496–509 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Šestan, M. et al. Nat. Immunol. https://doi.org/10.1038/s41590-024-01848-3 (2024).

    Article  PubMed  Google Scholar 

  5. Hart, B. L. Neurosci. Biobehav. Rev. 12, 123–137 (1988).

    Article  CAS  PubMed  Google Scholar 

  6. Goldberg, E. L. et al. Sci. Immunol. 4, eaav2026 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Tomlinson, K. L. et al. Cell Metab. 35, 1767–1781.e1766 (2023).

    Article  CAS  PubMed  Google Scholar 

  8. Dror, E. et al. Nat. Immunol. 18, 283–292 (2017).

    Article  CAS  PubMed  Google Scholar 

  9. Shaikh, S. R., Beck, M. A., Alwarawrah, Y. & MacIver, N. J. Nat. Rev. Endocrinol. 20, 136–148 (2024).

    Article  CAS  PubMed  Google Scholar 

  10. Costanzo, A. E. et al. PLoS ONE 10, e0120918 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Lopes, N. et al. Nat. Immunol. 22, 179–192 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Emily L. Goldberg.

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Goldberg, E.L. Glucose restriction in antiviral defence. Nat Immunol 25, 941–943 (2024). https://doi.org/10.1038/s41590-024-01849-2

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