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The hidden functional diversity of macrophages

Our work identifies previously unrecognized functional heterogeneity in tissue-resident interstitial macrophages. We have identified ten macrophage subsets, each thought to specifically contribute to recruiting and organizing cell types within tissues. Moreover, our findings suggest the diversity and division of labor extend to other macrophage populations previously considered homogeneous.

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Fig. 1: Chemokine expression reveals IM heterogeneity and division of labor.


  1. Gibbings, S. L. et al. Three unique interstitial macrophages in the murine lung at steady state. Am. J. Respir. Cell Mol. Biol. 57, 66–76 (2017). This study performed deep sequencing on three distinct IMs based on cell-surface markers, aligned IM genes across tissues, and demonstrated classical macrophage functions.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Aegerter, H., Lambrecht, B. N. & Jakubzick, C. V. Biology of lung macrophages in health and disease. Immunity 55, 1564–1580 (2022). This review highlights the heterogeneity and functionality of pulmonary macrophages and provides scRNA-seq and protein expression data that define lung mononuclear phagocytes.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Lee, S. H. et al. Dermis resident macrophages orchestrate localized ILC2 eosinophil circuitries to promote non-healing cutaneous leishmaniasis. Nat. Commun. 14, 7852 (2023). This study targets specific chemokine-expressing skin IMs and demonstrates their functional role in skin disease.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Mould, K. J. et al. Airspace macrophages and monocytes exist in transcriptionally distinct subsets in healthy adults. Am. J. Respir. Crit. Care Med. 203, 946–956 (2021). This study showed the extent of airspace macrophage subset heterogeneity in healthy human lungs via scRNA-seq.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Li, X. et al. ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALF. Life Sci, Alliance 5, e202201458 (2022). This study supports the findings in ref. 4 and identified 12 functionally distinct alveolar macrophage subsets such as various chemokine-expressing AM subsets.

    Article  CAS  PubMed  Google Scholar 

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This is a summary of: Li, X. et al. Coordinated chemokine expression defines macrophage subsets across tissues. Nat. Immunol. (2024).

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The hidden functional diversity of macrophages. Nat Immunol 25, 953–954 (2024).

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