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Identification of a human multipotent TH2 progenitor

In this study, we use a transcriptomic approach as a starting point to explore the heterogeneity of human GATA3-expressing lymphocytes across different tissues and disease contexts. We identify, characterize and functionally validate an abundant progenitor-like memory T cell population with the potential to sustain pathogenic TH2 cell inflammation.

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Fig. 1: Generation of a GATA3+ lymphocyte atlas.


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This is a summary of: Kratchmarov, R. et al. TCF1–LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases. Nat. Immunol. (2024).

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Identification of a human multipotent TH2 progenitor. Nat Immunol 25, 735–736 (2024).

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