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Baseline JAK–STAT signaling maintains immune cell homeostasis

Homeostatic immune cells remain perpetually vigilant against pathogens. We found that baseline JAK–STAT signaling supports the characteristic transcriptional and epigenetic state of homeostatic T cells and macrophages in mice. JAK–STAT signaling under homeostatic conditions was driven by signals from healthy tissue and did not require external immune stimuli.

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Fig. 1: Widespread effects of JAK–STAT mutants on homeostatic immune cells.


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This is a summary of: Fortelny, N. et al. JAK-STAT signaling maintains homeostasis in T cells and macrophages. Nat. Immunol. (2024).

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Baseline JAK–STAT signaling maintains immune cell homeostasis. Nat Immunol 25, 741–742 (2024).

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