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Self-sustaining inflammatory cycle causes memory impairment in neuropsychiatric lupus

Autoantibodies that develop in systemic lupus erythematosus (SLE) can cause long-term cognitive impairment that remains even after the systemic disease becomes quiescent. This study attributes the persistent cognitive symptoms of SLE to a self-sustaining neuroinflammatory process that continues indefinitely unless disrupted — which can be done using medications approved by the US Food and Drug Administration.

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Fig. 1: Outcomes of DNRAb-mediated neuronal damage.


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This is a summary of: Carroll, K. R. et al. Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression. Nat. Immunol. (2024).

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Self-sustaining inflammatory cycle causes memory impairment in neuropsychiatric lupus. Nat Immunol 25, 596–597 (2024).

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