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Baseline immune characteristics linked to pneumococcal vaccine responsiveness in older adults

The effectiveness of pneumococcal vaccines declines with age for unknown reasons. We studied the responses of older adults to the 23-valent PPSV23 and the 13-valent PCV13, identifying distinct baseline immune characteristics associated with vaccine responsiveness, including a cytotoxicity signature associated with weaker responses to PCV13.

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Fig. 1: Baseline immune characteristics associated with pneumococcal vaccine responsiveness.


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This is a summary of: Ravichandran, S. et al. Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults. Nat. Immunol. (2024).

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Baseline immune characteristics linked to pneumococcal vaccine responsiveness in older adults. Nat Immunol 25, 198–199 (2024).

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