Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Briefing
  • Published:

Human and mouse peritoneal macrophages and dendritic cells compared

Mouse macrophages express specialized genes particular to the organs they inhabit, but whether the same applies in humans is unclear. In human peritoneal fluid, we identified many macrophage phenotypes, including two specialized macrophage types that corresponded to distinct mouse peritoneal macrophages. However, their abundances were markedly different between species.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Mouse and human macrophages and dendritic cells gene expression profiles.


  1. Randolph, G. J. Tissue macrophages break dogma. Nat. Rev. Immunol. 21, 625 (2021). This short article covers the landmark studies over the past 15 years that have fueled a wave of research in macrophage biology, diversity and lifecycle.

    Article  CAS  PubMed  Google Scholar 

  2. Kim, K. W. et al. MHC II+ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes. J. Exp. Med. 213, 1951–1959 (2016). This paper reports the developmental origins and characteristics of a second resident peritoneal macrophage in mice that the present work reveals as a counterpart to CD1C+CD14+ human DC-like macrophages.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Zindel, J. et al. Primordial Gata6 macrophages function as extravascular platelets in sterile injury. Science 371, eabe0595 (2021). This article presents evidence in mice that Gata6+ macrophages drive surgical adhesions between organs in the body cavity.

    Article  CAS  PubMed  Google Scholar 

  4. Finlay, C. M. et al. T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity. Immunity 56, 1064–1081 (2023). This paper reveals a stepwise differentiation of monocytes to CD206+LYVE1+ macrophages to Gata6+ macrophages that is regulated by IL-4 from T cells in the context of parasite infection.

    Article  CAS  PubMed  Google Scholar 

  5. Zhang, N. et al. Expression of factor V in resident macrophages boosts host defense in the peritoneal cavity. J. Exp. Med. 216, 1291–1300 (2019). This article reports that Gata6+ mouse macrophages selectively express clotting factors, such as factor V, that enable peritoneal clots to trap microorganisms to prevent dissemination from the peritoneal cavity.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Han, J. et al. Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species. Nat. Immunol. (2024).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Human and mouse peritoneal macrophages and dendritic cells compared. Nat Immunol 25, 17–18 (2024).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing