The transcription factor NFAT5 regulates T cell exhaustion, a dysfunctional state caused by chronic exposure to antigen and other signals, during cancer but not during chronic viral infection.
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N.S.J. has consulted for Dragonfly Therapeutics, in areas unrelated to this topic.
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Buck, J., Joshi, N.S. Cancer- and infection-induced T cell exhaustion are distinct. Nat Immunol 24, 1604–1605 (2023). https://doi.org/10.1038/s41590-023-01624-9