Many transcription factors contain intrinsically disordered regions whose functions are not well characterized. An intrinsically disordered region in TCF-1 has now been found to have an essential function in coordinating T cell lineage commitment.
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The authors declare no competing interests.
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Liu, S., Zhao, K. Disorder-based T cell developmental order. Nat Immunol 24, 1602–1603 (2023). https://doi.org/10.1038/s41590-023-01623-w