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COVID-19

Vaccine-induced CD8+ T cells are key to protection from SARS-CoV-2

Nature Immunology volume 24, pages 1594–1596 (2023)Cite this article

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After vaccination, spike-specific CD8+ T cells play an important part in the immediate immune response to breakthrough SARS-CoV-2 infection, whereas the B cell and neutralizing antibody responses come into effect 2 weeks after infection.

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Fig. 1: Dynamics of the immune adaptive and humoral immune responses to vaccination and breakthrough infection.

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Acknowledgements

This work is supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (grant number 2018-I2M-2-002) and the UK Medical Research Council.

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Authors and Affiliations

  1. Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK

    Elie Antoun, Yanchun Peng & Tao Dong

  2. MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK

    Tao Dong

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  1. Elie Antoun
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  2. Yanchun Peng
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  3. Tao Dong
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Correspondence to Tao Dong.

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Antoun, E., Peng, Y. & Dong, T. Vaccine-induced CD8+ T cells are key to protection from SARS-CoV-2. Nat Immunol 24, 1594–1596 (2023). https://doi.org/10.1038/s41590-023-01621-y

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