Glioblastoma is a devastating primary brain tumor consisting of multiple cell populations. We identified TFPI2 as the crucial effector of the symbiotic interaction between glioblastoma stem cells and microglia. Blockade of this symbiosis inhibited tumor growth and synergized with an immune checkpoint inhibitor in mouse models of glioblastoma.
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This is a summary of: Pang, L. et al. Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma. Nat. Immunol. https://doi.org/10.1038/s41590-023-01605-y (2023).
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TFPI2 is key for cancer stem cell–microglia symbiosis in glioblastoma. Nat Immunol 24, 1612–1613 (2023). https://doi.org/10.1038/s41590-023-01610-1