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References
Wang, T. et al. Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs. Nat. Immunol. 24, 423–438 (2023).
Li, F. et al. Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection. Sci. Immunol. 7, eabj5761 (2022).
Aegerter, H. et al. Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection. Nat. Immunol. 21, 145–157 (2020).
Machiels, B. et al. A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes. Nat. Immunol. 18, 1310–1320 (2017).
Yao, Y. et al. Induction of autonomous memory alveolar macrophages requires T cell help and is critical to trained immunity. Cell 175, 1634–1650 (2018).
Netea, M. G., Quintin, J. & Van Der Meer, J. W. M. Trained immunity: a memory for innate host defense. Cell Host Microbe 9, 355–361 (2011).
Ginhoux, F. & Guilliams, M. Tissue-resident macrophage ontogeny and homeostasis. Immunity 44, 439–449 (2016).
Guilliams, M. et al. Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF. J. Exp. Med. 210, 1977–1992 (2013).
van de Laar, L. et al. Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages. Immunity 44, 755–768 (2016).
Kulikauskaite, J. & Wack, A. Teaching old dogs new tricks? The plasticity of lung alveolar macrophage subsets. Trends Immunol. 41, 864–877 (2020).
Hermesh, T., Moltedo, B., Moran, T. M. & López, C. B. Antiviral instruction of bone marrow leukocytes during respiratory viral infections. Cell Host Microbe 7, 343–353 (2010).
Aegerter, H., Lambrecht, B. N. & Jakubzick, C. V. Biology of lung macrophages in health and disease. Immunity 55, 1564–1580 (2022).
Gibbings, S. L. et al. Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages. Blood 126, 1357–1366 (2015).
Misharin, A. V. et al. Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. J. Exp. Med. 214, 2387–2404 (2017).
Serbina, N. V. & Pamer, E. G. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat. Immunol. 7, 311–317 (2006).
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C.S.I. and A.W. wrote the manuscript. J.K., H.A., F.L., F.P., C.V.J., M.G. and M.K. contributed conceptionally and helped to edit the text.
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Nature Immunology thanks Maziar Divangahi and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Primary Handling Editor: N. Bernard, in collaboration with the Nature Immunology team.
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Iliakis, C.S., Kulikauskaite, J., Aegerter, H. et al. The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function. Nat Immunol 24, 1639–1641 (2023). https://doi.org/10.1038/s41590-023-01602-1
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DOI: https://doi.org/10.1038/s41590-023-01602-1
