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T cell development

Doubling down to make killer T cells

Control of the alternative commitment of immature CD4+CD8+ T cells to the CD4+ or CD8+ lineage has long been the subject of intense scrutiny. A combination of CITE-seq and functional assays provides significant new insights into the distinct T cell antigen receptor signaling requirements for these lineage fates.

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Fig. 1: Distinct TCR signaling requirements for commitment of immature double-positive CD4+CD8+ cells to the single-positive CD4+ or CD8+ lineage.


  1. Steier, Z. et al. Nat. Immunol. (2023).

    Article  PubMed  Google Scholar 

  2. Lucas, B. & Germain, R. N. Immunity 5, 461–477 (1996).

    Article  CAS  PubMed  Google Scholar 

  3. Suzuki, H., Punt, J. A., Granger, L. G. & Singer, A. Immunity 2, 413–425 (1995).

    Article  CAS  PubMed  Google Scholar 

  4. Bosselut, R., Guinter, T. I., Sharrow, S. O. & Singer, A. J. Exp. Med. 197, 1709–1719 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Brugnera, E. et al. Immunity 13, 59–71 (2000).

    Article  CAS  PubMed  Google Scholar 

  6. Adachi, S. & Iwata, M. Cell Immunol. 215, 45–53 (2002).

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Dietmar Kappes.

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Kappes, D., Wiest, D.L. Doubling down to make killer T cells. Nat Immunol 24, 1407–1408 (2023).

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