Control of the alternative commitment of immature CD4+CD8+ T cells to the CD4+ or CD8+ lineage has long been the subject of intense scrutiny. A combination of CITE-seq and functional assays provides significant new insights into the distinct T cell antigen receptor signaling requirements for these lineage fates.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Steier, Z. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01584-0 (2023).
Lucas, B. & Germain, R. N. Immunity 5, 461–477 (1996).
Suzuki, H., Punt, J. A., Granger, L. G. & Singer, A. Immunity 2, 413–425 (1995).
Bosselut, R., Guinter, T. I., Sharrow, S. O. & Singer, A. J. Exp. Med. 197, 1709–1719 (2003).
Brugnera, E. et al. Immunity 13, 59–71 (2000).
Adachi, S. & Iwata, M. Cell Immunol. 215, 45–53 (2002).
The authors declare no competing interests.
About this article
Cite this article
Kappes, D., Wiest, D.L. Doubling down to make killer T cells. Nat Immunol 24, 1407–1408 (2023). https://doi.org/10.1038/s41590-023-01593-z