The functional heterogeneity of macrophages has ontological and microenvironmental bases, and differentially affects pathology. In pancreatitis, tissue-resident macrophages promote protective fibrosis that favors the maintenance of pancreatic homeostasis. In pancreatic ductal adenocarcinoma, they promote tumor progression by facilitating stromal desmoplasia.
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The authors declare no competing interests.
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Sica, A., Lazzeri, M. Specialization determines outcomes in inflammation and cancer. Nat Immunol 24, 1399–1401 (2023). https://doi.org/10.1038/s41590-023-01592-0