Presentation of signal peptides by HLA-E to natural killer cells prevents cell lysis via interactions with the inhibitory CD94–NKG2A receptor. A study now reveals an unexpected level of sophistication and heterogeneity in this receptor–ligand interaction.
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During the drafting of the article, Brinley John, the father of Jamie Rossjohn, passed away.
The authors declare no competing interests.
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Saunders, P.M., Brooks, A.G. & Rossjohn, J. Oyez, Oyez, Oyez!. Nat Immunol 24, 1052–1053 (2023). https://doi.org/10.1038/s41590-023-01541-x