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Neutrophils

Inflammaging aggravates stroke pathology

Nature Immunology volume 24, pages 887–888 (2023)Cite this article

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In mice and humans, changes in neutrophil phenotypes and functionality during aging aggravate thromboinflammation in ischemic brain injury and determine the pathology associated with strokes. In mice, inhibition of CXCL3 signaling and rejuvenation of bone marrow offer ways of restricting brain injury and improving stroke outcomes.

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Fig. 1: Aging-associated changes in neutrophils impact stroke outcome.

References

  1. Feigin, V. L. et al. New Engl. J. Med. 379, 2429–2437 (2018).

    Article  PubMed  Google Scholar 

  2. Van Avondt, K. et al. Immunol. Rev. 314, 357–375 (2023).

    Article  PubMed  Google Scholar 

  3. Gullotta, G. S. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01505-1 (2023).

    Article  PubMed  Google Scholar 

  4. Kang, L. et al. Nat. Commun. 11, 2488 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Engelmann, B. & Massberg, S. Nat. Rev. Immunol. 13, 34–45 (2013).

    Article  CAS  PubMed  Google Scholar 

  6. Casanova-Acebes, M. et al. Cell 153, 1025–1035 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Roy-O’Reilly, M. A. et al. Aging 12, 436–461 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Zhang, D. et al. Nature 525, 528–532 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Vafadarnejad, E. et al. Circ. Res. 127, e232–e249 (2020).

    Article  CAS  PubMed  Google Scholar 

  10. Chen, R. L., Balami, J. S., Esiri, M. M., Chen, L. K. & Buchan, A. M. Nat. Rev. Neurol. 6, 256–265 (2010).

    Article  PubMed  Google Scholar 

  11. Ballesteros, I. et al. Cell 183, 1282–1297.e1218 (2020).

    Article  CAS  PubMed  Google Scholar 

  12. Barkaway, A. et al. Immunity 54, 1494–1510.e1497 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The authors’ work is supported by the German Centre for Cardiovascular Research (DZHK) and German Ministry of Education and Research (BMBF) (grants 81Z0600204 to C.S. and 81Z0600201 to S.M.); Deutsche Forschungsgemeinschaft CRC TRR332 project A6 (C.S.); and the European Research Council (ERC) (grant 833440 to S.M.).

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Authors and Affiliations

  1. Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany

    Christian Schulz & Steffen Massberg

  2. DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany

    Christian Schulz & Steffen Massberg

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  1. Christian Schulz
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  2. Steffen Massberg
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Correspondence to Christian Schulz or Steffen Massberg.

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Schulz, C., Massberg, S. Inflammaging aggravates stroke pathology. Nat Immunol 24, 887–888 (2023). https://doi.org/10.1038/s41590-023-01516-y

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