Bystander activation that leads to expression of IL-9 in effector TH9 cells is induced by a TCR-independent, STAT-dependent mechanism and may represent a new strategy for therapeutic intervention to treat TH9-induced pathologies in vivo.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Kaplan, M. H., Hufford, M. M. & Olson, M. R. Nat. Rev. Immunol. 15, 295–307 (2015).
Tan, C. et al. J. Immunol. 185, 6795–6801 (2010).
Micossé, C. et al. Sci. Immunol. https://doi.org/10.1126/sciimmunol.aat5943 (2019).
Son, A. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01501-5 (2023).
Kaplan, M. H. Semin. Immunopathol. 39, 11–20 (2017).
Ulrich, B. J. et al. Sci. Immunol. 7, eabg9296 (2022).
Licona-Limón, P. et al. Immunity 39, 744–757 (2013).
Schwartz, D. M. et al. Immunity 50, 106–120 (2019).
Olson, M. R. et al. J. Immunol.y 198, 4352–4359 (2017).
Murugaiyan, G., Beynon, V., Pires Da Cunha, A., Joller, N. & Weiner, H. L. J. Immunol. 189, 5277–5283 (2012).
Maizels, R. M. & McSorley, H. J. J. Allergy Clin. Immunol. 138, 666–675 (2016).
Lu, Y. et al. J. Clin. Invest. 122, 4160–4171 (2012).
This work was supported by the Consejo Nacional de Ciencia y Tecnología (CONACYT) grant FORDECYT-PRONACE-303027 and DGAPA (IN220823-PAPIIT) to P.L.L. O.M.P received a fellowship from CONACYT (736162). We thank S. Erickson and I. Licona-Limón for critical reading of the manuscript.
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Muñoz-Paleta, O., Licona-Limón, P. JAKing up IL-9 expression in TH9 cells. Nat Immunol 24, 891–892 (2023). https://doi.org/10.1038/s41590-023-01509-x