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TH9 cells

JAKing up IL-9 expression in TH9 cells

Nature Immunology volume 24, pages 891–892 (2023)Cite this article

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Bystander activation that leads to expression of IL-9 in effector TH9 cells is induced by a TCR-independent, STAT-dependent mechanism and may represent a new strategy for therapeutic intervention to treat TH9-induced pathologies in vivo.

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Fig. 1: Bystander activation of resting TH9 cells by IL-2 and IL-4 promotes IL9 expression and TH9-driven inflammation in vivo.

References

  1. Kaplan, M. H., Hufford, M. M. & Olson, M. R. Nat. Rev. Immunol. 15, 295–307 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Tan, C. et al. J. Immunol. 185, 6795–6801 (2010).

    Article  CAS  PubMed  Google Scholar 

  3. Micossé, C. et al. Sci. Immunol. https://doi.org/10.1126/sciimmunol.aat5943 (2019).

    Article  PubMed  Google Scholar 

  4. Son, A. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01501-5 (2023).

    Article  PubMed  Google Scholar 

  5. Kaplan, M. H. Semin. Immunopathol. 39, 11–20 (2017).

    Article  CAS  PubMed  Google Scholar 

  6. Ulrich, B. J. et al. Sci. Immunol. 7, eabg9296 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Licona-Limón, P. et al. Immunity 39, 744–757 (2013).

    Article  PubMed  Google Scholar 

  8. Schwartz, D. M. et al. Immunity 50, 106–120 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Olson, M. R. et al. J. Immunol.y 198, 4352–4359 (2017).

    Article  CAS  Google Scholar 

  10. Murugaiyan, G., Beynon, V., Pires Da Cunha, A., Joller, N. & Weiner, H. L. J. Immunol. 189, 5277–5283 (2012).

    Article  CAS  PubMed  Google Scholar 

  11. Maizels, R. M. & McSorley, H. J. J. Allergy Clin. Immunol. 138, 666–675 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Lu, Y. et al. J. Clin. Invest. 122, 4160–4171 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This work was supported by the Consejo Nacional de Ciencia y Tecnología (CONACYT) grant FORDECYT-PRONACE-303027 and DGAPA (IN220823-PAPIIT) to P.L.L. O.M.P received a fellowship from CONACYT (736162). We thank S. Erickson and I. Licona-Limón for critical reading of the manuscript.

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  1. Departamento de Biología Celular y del Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México City, México

    Ofelia Muñoz-Paleta & Paula Licona-Limón

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  1. Ofelia Muñoz-Paleta
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  2. Paula Licona-Limón
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Correspondence to Paula Licona-Limón.

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Muñoz-Paleta, O., Licona-Limón, P. JAKing up IL-9 expression in TH9 cells. Nat Immunol 24, 891–892 (2023). https://doi.org/10.1038/s41590-023-01509-x

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