Deletion of TFAM, the master regulator of mitochondrial transcription and translation, limits germinal center reactions. Notably, TFAM affects several processes beyond bioenergetics, such as migration, signaling, somatic hypermutation and redox balance.
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Jellusova, J. Germinal centers FAMished without TFAM. Nat Immunol 24, 893–894 (2023). https://doi.org/10.1038/s41590-023-01507-z