Regulatory T (Treg) cells respond to interferon-γ (IFNγ) during viral infection and polarize to a T helper (TH)1-like state. Such Treg cells possess effector functions, such as the production of IFNγ, yet remain stable and potently limit virus-specific effector T cell function, CD8+ T cell proliferation and the formation of central memory T cells.
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References
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This is a summary of: Gocher-Demske, A. M. et al. IFNγ-induction of TH1-like regulatory T cells controls antiviral responses. Nat. Immunol. https://doi.org/10.1038/s41590-023-01453-w (2023).
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IFNγ guides the suppressive activity of Treg cells during viral infection. Nat Immunol 24, 751–752 (2023). https://doi.org/10.1038/s41590-023-01496-z
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DOI: https://doi.org/10.1038/s41590-023-01496-z
