New work from Udeochu, Amin, Huang, and colleagues provides mechanistic insights into how the tau protein engages the cGAS–STING pathway to elicit antiviral responses in Alzheimer’s disease. This signaling axis diminishes the MEF2C transcriptional network in neurons critical for maintaining cognitive function.
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The authors declare no competing interests.
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Salvador, A.F.M., Kipnis, J. Resilient brains run out of (c)GAS. Nat Immunol 24, 741–742 (2023). https://doi.org/10.1038/s41590-023-01485-2