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Inflammasomes

Ten things to know about NLRP10

Nature Immunology volume 24, pages 561–562 (2023)Cite this article

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The NLRP10 protein is found to form an inflammasome complex in response to mitochondrial damage. Loss of NLRP10 from colonic epithelia promotes inflammatory bowel disease in a mouse model, while a variant predisposing to atopic dermatitis also shows loss of function.

The identification of a trigger for any innate immune sensor is a watershed moment, as it permits the dissection of that sensor’s function and contribution to pathology. In this issue of Nature Immunology, Próchnicki et al.1 identify a phospholipase C activator — 3m3-FBS — as a chemical trigger of mitochondrial destabilization, and the first known agent to cause cells to assemble a NLRP10-based inflammasome complex. Meanwhile, in an accompanying paper, Zheng et al.2 identify the same trigger, and also define a role for NLRP10 in distal colonic epithelia, where it is required to limit disease in a dextran sodium sulfate (DSS)-induced model of inflammatory bowel disease in mice.

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Fig. 1: 3m3-FBS activates the NLRP10 inflammasome via damaged mitochondria.

References

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Authors and Affiliations

  1. Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

    Seth L. Masters

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  1. Seth L. Masters
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Correspondence to Seth L. Masters.

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Competing interests

S.L.M. is a scientific advisor for Odyssey Therapeutics and NRG Therapeutics.

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Masters, S.L. Ten things to know about NLRP10. Nat Immunol 24, 561–562 (2023). https://doi.org/10.1038/s41590-023-01466-5

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