The NLRP10 protein is found to form an inflammasome complex in response to mitochondrial damage. Loss of NLRP10 from colonic epithelia promotes inflammatory bowel disease in a mouse model, while a variant predisposing to atopic dermatitis also shows loss of function.
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S.L.M. is a scientific advisor for Odyssey Therapeutics and NRG Therapeutics.
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Masters, S.L. Ten things to know about NLRP10. Nat Immunol 24, 561–562 (2023). https://doi.org/10.1038/s41590-023-01466-5