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Microgliopathies

A polarizing answer — microglia in Nasu-Hakola disease

Nature Immunology volume 24, pages 379–381 (2023)Cite this article

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A new study by Zhou et al. identifies a unique microglia state in Nasu-Hakola disease and new potential therapeutic targets.

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Fig. 1: Nasu-Hakola disease transcriptional map is notable for a unique microglia and macrophage state.

References

  1. Paloneva, J. et al. Am. J. Hum. Genet. 71, 656–662 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Zhou, Y. et al. Nat Immunol. https://doi.org/10.1038/s41590-022-01403-y (2023).

    Article  PubMed  Google Scholar 

  3. Ransohoff, R. M. Nat. Neurosci. 19, 987–991 (2016).

    Article  CAS  PubMed  Google Scholar 

  4. Satoh, J.-I., Kino, Y., Yanaizu, M. & Saito, Y. Intractable Rare Dis. Res. 7, 32–36 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Paolicelli, R. C. et al. Neuron 110, 3458–3483 (2022).

    Article  CAS  PubMed  Google Scholar 

  6. Paloneva, B. M. & J et al. Neurology 56, 1552–1558 (2001).

    Article  CAS  PubMed  Google Scholar 

  7. Jairaman, A. et al. Elife 11, e73021 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Konishi, H. & Kiyama, H. Neurochem. Int. 141, 104878 (2020).

    Article  CAS  PubMed  Google Scholar 

  9. Ennerfelt, H. et al. Cell 185, 4135–4152.e22 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Wang, S. et al. Cell 185, 4153–4169.e19 (2022).

    Article  CAS  PubMed  Google Scholar 

  11. Chakrabarty, P. et al. Neuron 85, 519–533 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Sumpter, T. L. et al. J. Immunol. 186, 1970–1980 (2011).

    Article  CAS  PubMed  Google Scholar 

  13. Turnbull, I. R. & Colonna, M. Nat. Rev. Immunol. 7, 155–161 (2007).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

M.L.B. would like to thank H. Song, G. Ming and other lab members for their continued support. Work is supported by NINDS R25 NS065745.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Neurology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Mariko L. Bennett

  2. Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Mariko L. Bennett

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  1. Mariko L. Bennett
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Correspondence to Mariko L. Bennett.

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M.L.B. is a former consultant for Alector LLC.

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Bennett, M.L. A polarizing answer — microglia in Nasu-Hakola disease. Nat Immunol 24, 379–381 (2023). https://doi.org/10.1038/s41590-023-01440-1

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