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Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form

Nature Immunology volume 24, pages 412–413 (2023)Cite this article

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The Original Article was published on 13 February 2023

replying to Hsu et al. Nature Immunology https://doi.org/10.1038/s41590-023-01423-2 (2023)

With a great deal of interest we read the comment related to our manuscript entitled ‘Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation’1. We greatly appreciate the independent and thorough replication, confirmation and extension of our findings. In line with our results, Hsu and colleagues demonstrate that delipidated aplipoprotein C3 (ApoC3) induces activation of the NLRP3 inflammasome and subsequent release of interleukin (IL)-1β in monocytes.

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Fig. 1: Modification of the association between an Nlrp3 activating genetic variant and cardiovascular mortality by triglycerides and ApoC3.

References

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Author information

Author notes

  1. These authors contributed equally: Ulrich Laufs and Thimoteus Speer.

Authors and Affiliations

  1. Department of Internal Medicine IV, Nephrology and Hypertension, Saarland University, Homburg/Saar, Germany

    Stephen Zewinger, Sarah Triem, Mira Klug, Stefan J. Schunk, David Schmit, Anna Paschen, Tobias Herter, Urban Sester & Danilo Fliser

  2. Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA

    Jochen Reiser & Eunsil Hahm

  3. Institute for Molecular Cardiovascular Research, RWTH Aachen University Hospital, Aachen, Germany

    Vera Jankowski & Joachim Jankowski

  4. Molecular Biophysics, Center of Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg/Saar, Germany

    Dalia Alansary & Barbara A. Niemeyer

  5. Department of Nephrology, University Hospital of the RWTH Aachen, Aachen, Germany

    Rafael Kramann

  6. Division of Nephrology and Transplantation, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands

    Rafael Kramann

  7. Institute for Clinical and Experimental Surgery, Saarland University, Homburg/Saar, Germany

    Christina Körbel, Emmanuel Ampofo, Matthias W. Laschke & Michael D. Menger

  8. Department of Internal Medicine III, Cardiology, Saarland University, Homburg/Saar, Germany

    Simina-Ramona Selejan & Michael Böhm

  9. Department of Cardiology, University Hospital Leipzig, Leipzig, Germany

    Susanne Gaul & Ulrich Laufs

  10. Department of Internal Medicine, Divison of Angiology, Medical University Graz, Graz, Austria

    Günther Silbernagel

  11. Department of Transplant and Infection Immunology, Saarland University, Homburg/Saar, Germany

    Martina Sester

  12. RUB-University Hospital Minden, Minden, Germany

    Gunter Aßmann

  13. Department of Internal Medicine V, Pneumology and Intensive Care Medicine, Saarland University, Homburg/Saar, Germany

    Robert Bals

  14. Molecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University Graz, Graz, Austria

    Gerhard Kostner

  15. Biointerface Laboratory, RWTH Aachen University Hospital, Aachen, Germany

    Willi Jahnen-Dechent

  16. Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland

    Lucia Rohrer

  17. Medical Clinic V (Nephrology, Rheumatology, Hypertensiology, Endocrinology, Diabetology), Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany

    Winfried März

  18. Synlab Academy, Synlab Holding Germany GmbH, Mannheim, Germany

    Winfried März

  19. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria

    Winfried März

  20. University of Maastricht, CARIM School for Cardiovascular Diseases, Maastricht, the Netherlands

    Joachim Jankowski

  21. Institute of Molecular Health Science, ETH, Zurich, Switzerland

    Manfred Kopf

  22. Institute of Innate Immunity, Bonn University, Bonn, Germany

    Eicke Latz

  23. Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA

    Eicke Latz

  24. German Center of Neurodegenerative Diseases (DZNE), Bonn, Germany

    Eicke Latz

  25. Department of Internal Medicine 4, Nephrology, Goethe University, Frankfurt/Main, Germany

    Thimoteus Speer

  26. Else Kroener Fresenius Center for Nephrological Research, Goethe University, Frankfurt/Main, Germany

    Thimoteus Speer

Authors
  1. Stephen Zewinger
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  2. Jochen Reiser
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  3. Vera Jankowski
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  4. Dalia Alansary
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  5. Eunsil Hahm
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  6. Sarah Triem
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  7. Mira Klug
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  8. Stefan J. Schunk
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  9. David Schmit
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  10. Rafael Kramann
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  11. Christina Körbel
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  14. Simina-Ramona Selejan
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  15. Anna Paschen
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  17. Susanne Gaul
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  18. Günther Silbernagel
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  19. Martina Sester
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  20. Urban Sester
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  21. Gunter Aßmann
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  22. Robert Bals
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  23. Gerhard Kostner
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  24. Willi Jahnen-Dechent
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  25. Michael D. Menger
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  26. Lucia Rohrer
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  27. Winfried März
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  28. Michael Böhm
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  29. Joachim Jankowski
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  30. Manfred Kopf
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  31. Eicke Latz
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  32. Barbara A. Niemeyer
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  33. Danilo Fliser
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  34. Ulrich Laufs
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  35. Thimoteus Speer
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Contributions

S.Z., W.M., U.L., and T.S. wrote the manuscript. S.Z. and T.S. performed the analyses. J.R., V.J., D.A., E.H., S.T., M.K., S.J.S., D.S., R.K., C.K., E.A., M.W.L., S.R.S., A.P., T.H., S.G., G.S., M.S., U.S., G.A., R.B., G.K., W.J.D., M.D.M., L.R., M.B., J.J., M.K., E.L., B.A.N., and D.F. critically revised the manuscript.

Corresponding author

Correspondence to Thimoteus Speer.

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The authors declare no competing interests.

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Zewinger, S., Reiser, J., Jankowski, V. et al. Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form. Nat Immunol 24, 412–413 (2023). https://doi.org/10.1038/s41590-023-01424-1

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