Human resident memory T (TRM) cells clonally segregate in distinct tissues, with gene expression signatures tailored to those sites. Hence, beyond a shared language of residency, TRM cells may acquire local dialects to provide site-specific immunity.
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The authors declare no competing interests.
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Maurice, N.J., Jameson, S.C. Resident memory T cells develop regional dialects. Nat Immunol 24, 209–210 (2023). https://doi.org/10.1038/s41590-022-01416-7