TH17 cells combat infection but can also drive pathological inflammation. A TH17 cell NLRP3–caspase-8–caspase-3–GSDME axis is now shown to release the alarmin IL-1α without triggering cell death.
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Groom, J.R., Vince, J.E. IL-1α-releasing TH17 cells live long and prosper. Nat Immunol 24, 205–206 (2023). https://doi.org/10.1038/s41590-022-01412-x