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Regulatory T cells

Check(point) yourself before you wreck yourself in tumors

Expression of the inhibitory receptor PD-1 on regulatory T cells in the tumor microenvironment provides intrinsic stabilization, proliferation and metabolic rewiring signals to restrain tumor immunity.

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Fig. 1: PD-1 promotes Treg cell stability in the tumor microenvironment.

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Correspondence to Peter T. Sage.

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Lee, JM., Sage, P.T. Check(point) yourself before you wreck yourself in tumors. Nat Immunol 24, 10–11 (2023). https://doi.org/10.1038/s41590-022-01391-z

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