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Immune surveillance

Excess lipids on endosomes dictate NLRP3 localization and inflammasome activation

Nature Immunology volume 24, pages 3–4 (2023)Cite this article

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Diverse inflammasome stimuli recruit NLRP3 to dysfunctional endosomes via interactions with lipids that accumulate in excess on these organelles. Excess lipid detection may be a common principle that explains NLRP3 function in health and disease.

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Fig. 1: Recruitment of NLRP3 to excess lipids on dysfunctional endosomes ensures efficient inflammasome activities.

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Acknowledgements

This work was supported by National Institutes of Health (NIH) grants AI133524, AI093589, AI116550 and P30DK34854.

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  1. Division of Gastroenterology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA

    Jonathan C. Kagan

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  1. Jonathan C. Kagan
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Correspondence to Jonathan C. Kagan.

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Competing interests

J.C.K. consults and holds equity in Corner Therapeutics, Larkspur Biosciences and Neumora Therapeutics. None of these relationships influenced this work.

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Kagan, J.C. Excess lipids on endosomes dictate NLRP3 localization and inflammasome activation. Nat Immunol 24, 3–4 (2023). https://doi.org/10.1038/s41590-022-01364-2

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